OCTAD: an open workspace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features

Billy Zeng, Benjamin S. Glicksberg, Patrick Newbury, Evgeny Chekalin, Jing Xing, Ke Liu, Anita Wen, Caven Chow, Bin Chen

Published: 2020-12-22 DOI: 10.1038/s41596-020-00430-z

gene expression

drug discovery

precision medicine

therapeutic screening

OCTAD

AI 解读

Generation of mouse–human chimeric embryos

Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues

Decoding personal biotic and abiotic airborne exposome

A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys

Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds

Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst

Neuroscience robotics for controlled induction and real-time assessment of hallucinations

Scanorama: integrating large and diverse single-cell transcriptomic datasets

Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

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As the field of precision medicine progresses, treatments for patients with cancer are starting to be tailored to their molecular as well as their clinical features. The emerging cancer subtypes defined by these molecular features require that dedicated r
Introduction
Materials
Procedure 1
Procedure 2
Troubleshooting
Timing
Anticipated results
References
ACKNOWLEDGMENTS

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OCTAD: an open workspace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features

Extended

Extended Data Fig. 1 Screenshots of the web portal.

Supplementary information

Supplementary Information

Reporting Summary

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