Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

Julia Vallverdú, Raquel A. Martínez García de la Torre, Inge Mannaerts, Stefaan Verhulst, Ayla Smout, Mar Coll, Silvia Ariño, Teresa Rubio-Tomás, Beatriz Aguilar-Bravo, Celia Martínez-Sánchez, Delia Blaya, Catherine M. Verfaillie, Leo A. van Grunsven, Pau Sancho-Bru

Published: 2021-04-15 DOI: 10.1038/s41596-021-00509-1

induced pluripotent stem cells

hepatic stellate cells

differentiation protocol

drug screening

3D hepatic spheroids

AI 解读

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Heterogeneity（异质性）

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Hepatic stellate cells (HSCs) are nonparenchymal liver cells responsible for extracellular matrix homeostasis and are the main cells involved in the development of liver fibrosis following injury. The lack of reliable sources of HSCs has hence limited the
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ACKNOWLEDGMENTS

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Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

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